Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote, Antipyretic Analgesics and NSAIDs, Blood System Agents, Cardiovascular Agents, Central Nervous System Agents, Disinfectant and Preservatives, Electrolyte Balance and Dialysis Agents, Endocrine System Agents, Urinary System Agents, Vitamins, Amino Acids and Coenzymes
Medicine Grade, Tech Grade
Packaging & Delivery
1g/bag, 1kg/bag or 25kg/fiber drum or as demand
within 1-3 days
Chemical Name: Tretinoin CAS No.: 302-79-4
Product category: APIs Molecular Fomula: C20H28O2
Molecular weight: 300.44
Appearance:Yellow to light orange crystalline powder
Physical property of :
Tretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia, and is sold for this indication by Roche under the brand name Vesanoid. It is also available as a generic.
Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene. This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia. ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.
Specification of :
Yellow to light orange crystalline powder
Loss on drying
Residue on ignition
Purpose and function of :
1. Retinoic Acid/Tretinoin is widely applied in pharmaceutical field, mainly used for the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc..Retinoic Acid/Tretinoin can be made into tretinoin or retinoic acid cream to cure acne or other unhealthy skin.
2. Retinoic Acid/Tretinoin is used for skin keratinocytes-resistant drugs and cell-induced differentation drug.