Tretinoin

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US $1-10 / Gram | 1 Gram/Grams (Min. Order)
Supply Ability:
1000 Kilogram/Kilograms per Week
Port:
shanghai or qingdao
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Overview
Quick Details
CAS No.:
302-79-4
Other Names:
VITAMIN A ACID
MF:
C20H28O2
EINECS No.:
206-129-0
Type:
Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antidote, Antipyretic Analgesics and NSAIDs, Blood System Agents, Cardiovascular Agents, Central Nervous System Agents, Disinfectant and Preservatives, Electrolyte Balance and Dialysis Agents, Endocrine System Agents, Urinary System Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard:
Medicine Grade, Tech Grade
Brand Name:
ZHONGWEI
Model Number:
ZWLLL
Purity:
98.0%~102%
MW:
300.44
Melting point:
180-181 °C(lit.)
storage temp.:
2-8°C
form:
powder
Appearance:
yellow
Water Solubility:
insoluble
Merck:
14,8165
BRN:
2057223
Packaging & Delivery
Packaging Details
1g/bag, 1kg/bag or 25kg/fiber drum or as demand
Delivery Time
within 1-3 days
Product Description

I

 

Quick Details 

Chemical Name:  Tretinoin
CAS No.: 302-79-4

Product category: APIs
Molecular Fomula:  C20H28O2

Molecular weight: 300.44

Appearance: Yellow to light orange crystalline powder

Assay98.0%~102%

 

Physical property of :

 

Tretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia, and is sold for this indication by Roche under the brand name Vesanoid. It is also available as a generic.

Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia  gene. This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia. ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.

 

Specification of :

 

Inspection Standard

Appearance

Yellow to light orange crystalline powder

Melting Point

About 182°C

Solubility 

Conforms

Identification

Positive

Loss on drying

≤0.5%

Heavy Metals

≤0.002%

Residue on ignition

≤0.1%

Related Substances

≤0.5%

Isotretinoin 

≤5.0%

Assay

 

98.0%~102%

 

 

 

Purpose and function of :

 

1. Retinoic Acid/Tretinoin is widely applied in pharmaceutical field, mainly used for the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc..Retinoic Acid/Tretinoin can be made into tretinoin or retinoic acid cream to cure acne or other unhealthy skin.

 

2. Retinoic Acid/Tretinoin is used for skin keratinocytes-resistant drugs and cell-induced differentation drug.

 

Packaging of :  

1g/bag, 1kg/bag or 25kg/fiber drum or as demand

 

 

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